کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1409264 | 1501794 | 2012 | 6 صفحه PDF | دانلود رایگان |
The synthesis and DNA photocleavage studies of furano[3,2-c]-1,2,3,4-tetrahydroquinolines have been reported. Sm(III)nitrate was found to be an efficient for the Diels–Alder reaction of aryl amines with 2,3-dihydrofuran to offer the corresponding furano[3,2-c]-1,2,3,4-tetrahydroquinolines derivatives as a mixture of cis/trans stereoisomers in moderate yields. The aqueous solubility of acid catalyst can be recycled without significant loss of activity. The DNA photocleavage studies shows that, the cis/trans stereoisomers are good DNA cleavage mimic in terms of molecular structure.
Highlight
► We have developed an convenient alternative methodology for the synthesis of furano[3,2-c]quinolines.
► Sm(III) was a good oxidising agent and importantly it act as a Lewis acid catalyst in the formation of C–C bond.
► The DNA photocleavage property of furano[3,2-c]quinolines has been investigated by agarose gel electrophoresis.
► We found that the stereoisomers are good DNA cleavage mimic in terms of molecular structure.
Journal: Journal of Molecular Structure - Volume 1020, 8 August 2012, Pages 142–147