Synthesis, growth, characterization, structure and molecular docking studies of 1-[(E)-{[4-(morpholin-4-yl)phenyl]imino} methyl]naphthalen-2-ol single crystal: A potential antimicrobial agent

• Asymmetric unit contains two crystallographically independent molecules in different orientations.
• Morpholine ring adopts chair conformation.
• Compound exhibits potent antimicrobial activities against Gram-positive, Gram-negative bacteria and yeast.
• Morpholine derivative exhibits good inhibition against anti-cancer protein Hsp90.

High-quality single crystals of 1-[(E)-{[4-(Morpholin-4-yl)phenyl]imino}methyl]naphthalen-2-ol were grown by slow evaporation method using ethylacetate solution at room temperature and the sample is characterized by FTIR, UV–visible, NMR and single crystal X-ray diffraction studies. The crystal structure was solved by direct methods and refined by full-matrix least-squares procedure to a final reliability value of 0.047. The asymmetric unit contains two crystallographically independent molecules in different orientations. The weak O- -H⋯N and C- -H⋯π interactions are responsible for the stability of the molecules in the unit cell. The antimicrobial activity of the compound was screened using different species of bacteria and for their ability to inhibit the heat shock protein 90(Hsp90). Molecular docking studies also supported the work.