کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1410676 | 1501828 | 2011 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Insight into the protonation and K(I)-interaction of the inositol 1,2,3-trisphosphate as provided by 31P NMR and theoretical calculations
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Animal cells contain a pool of inositol phosphates whose biological function is still under current investigation. Ins(1,2,3)P3 is probably an important safe chelator of iron cations not strongly bound to proteins. In order to clarify its biological functions, Ins(1,2,3)P3 chemistry under physiological conditions must be completely elucidated. The protonation and complexation behaviour of Ins(1,2,3)P3 has been recently studied under these conditions by potentiometry. Under simulated physiological conditions it forms the protonated species H2L4â and H3L3â. The presence of high concentrations of potassium in intracellular compartments causes the formation of two predominant Ins(1,2,3)P3 complexes: [K(HL)]4â and [K(H2L)]3â, in the absence of iron. In this work we expand part of this macroscopic knowledge to the inframolecular level, by 31P NMR measurements and focusing on the protonation and complexation of this biologically relevant molecule to potassium. We complete this study with theoretical calculations which lead us to predict the geometries of every form of the ligand and their relative stabilities. The influence of the ring conformation in protonated and complexed forms is also discussed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 986, Issues 1â3, 14 February 2011, Pages 75-85
Journal: Journal of Molecular Structure - Volume 986, Issues 1â3, 14 February 2011, Pages 75-85
نویسندگان
Nicolás Veiga, Julia Torres, Gabriel González, Kerman Gómez, David Mansell, Sally Freeman, Sixto DomÃnguez, Carlos Kremer,