کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1410724 | 985373 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Conformational analysis of a quinolonic ribonucleoside with anti-HSV-1 activity Conformational analysis of a quinolonic ribonucleoside with anti-HSV-1 activity](/preview/png/1410724.png)
The infections caused by the Herpes Simplex Virus are one of the most common sources of diseases in adults and several natural nucleoside analogues are currently used in the treatment of these infections. In vitro tests of a series of quinolonic ribonucleosides derivatives synthesized by part of our group indicated that some of them have antiviral activity against HSV-1.The conformational analysis of bioactive compounds is extremely important in order to better understand their chemical structures and biological activity. In this work, we have carried out a nuclear relaxation NMR study of 6-Me ribonucleoside derivative in order to determine if the syn or anti conformation is preferential. The NMR analysis permits the determination of inter-atomic distances by using techniques which are based on nuclear relaxation and related phenomena. Those techniques are non-selective longitudinal or spin–lattice relaxation rates and NULL pulse sequence, which allow the determination of distances between pairs of hydrogen atoms. The results of NMR studies were compared with those obtained by molecular modeling.
Journal: Journal of Molecular Structure - Volume 985, Issue 1, 15 January 2011, Pages 1–4