Preparation and spectroscopic characterization of metal complexes of gliquidone

Complexes of gliquidone with Mg(II), Ca(II), Cr(II), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) were obtained in methanolic solution to study the interaction of the drug with essential and trace elements present in human body or co administered during multivitamin therapy. These complexes were then characterized by spectroscopic techniques involving IR, 1H NMR, CHN elemental analysis, atomic absorption analysis and conductometric titrations. In most of the complexes, it is observed that the N–H stretch of sulfonamide and amide has disappeared.