کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1411702 | 1501875 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Structural and thermodynamic analysis of the hetero-association of theophylline with aromatic drug molecules
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The hetero-association of theophylline (THP) with other biologically-active aromatic molecules (e.g. the anti-cancer drugs daunomycin and novantrone, the antibiotic norfloxacin, the vitamin flavin-mononucleotide and two mutagens ethidium bromide and proflavine) has been studied by NMR in aqueous-salt solution (0.1 M Na-phosphate buffer, pD 7.1). It was found that THP shows an essentially similar hetero-association ability as caffeine (CAF) towards aromatic drugs, except for novantrone (NOV), which has much less affinity to THP than CAF as a result of energetically unfavourable orthogonal orientation of the chromophores of THP and NOV in the hetero-complex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 889, Issues 1–3, 29 October 2008, Pages 229–236
Journal: Journal of Molecular Structure - Volume 889, Issues 1–3, 29 October 2008, Pages 229–236
نویسندگان
D.D. Andrejuk, A.A. Hernandez Santiago, V.V. Khomich, V.K. Voronov, D.B. Davies, M.P. Evstigneev,