کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1420390 | 986360 | 2016 | 13 صفحه PDF | دانلود رایگان |

• We combine biomechanical tests, μCT and histomorphometry to study a minipig model.
• We investigate osseointegration of titanium implants with innovative scaffolds.
• We measure means of IT values, RFA, BIC, BMD and stereological values of bone.
• We provide quantitative results on bone structure and mechanical properties.
ObjectivesTo present a practical approach that combines biomechanical tests, microcomputed tomography (μCT) and histomorphometry, providing quantitative results on bone structure and mechanical properties in a minipig model, in order to investigate the specific response to an innovative dental biomaterial.MethodsTitanium implants with innovative three-dimensional scaffolds were inserted in the tibias of 4 minipigs. Primary stability and osseointegration were investigated by means of insertion torque (IT) values, resonance frequency analysis (RFA), bone-to-implant contact (BIC), bone mineral density (BMD) and stereological measures of trabecular bone.ResultsA significant positive correlation was found between IT and RFA (r = 0.980, p = 0.0001). BMD at the implant sites was 18% less than the reference values (p = 0.0156). Peri-implant Tb.Th was 50% higher, while Tb.N was 50% lower than the reference zone (p < 0.003) and they were negatively correlated (r = −0.897, p = 0.006).SignificanceμCT increases evaluation throughput and offers the possibility for qualitative three-dimensional recording of the bone–implant system as well as for non-destructive evaluation of bone architecture and mineral density, in combination with conventional analysis methods. The proposed multimodal approach allows to improve accuracy and reproducibility for peri-implant bone measurements and could support future investigations.
Journal: Dental Materials - Volume 32, Issue 6, June 2016, Pages 794–806