کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1420390 986360 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model
چکیده انگلیسی


• We combine biomechanical tests, μCT and histomorphometry to study a minipig model.
• We investigate osseointegration of titanium implants with innovative scaffolds.
• We measure means of IT values, RFA, BIC, BMD and stereological values of bone.
• We provide quantitative results on bone structure and mechanical properties.

ObjectivesTo present a practical approach that combines biomechanical tests, microcomputed tomography (μCT) and histomorphometry, providing quantitative results on bone structure and mechanical properties in a minipig model, in order to investigate the specific response to an innovative dental biomaterial.MethodsTitanium implants with innovative three-dimensional scaffolds were inserted in the tibias of 4 minipigs. Primary stability and osseointegration were investigated by means of insertion torque (IT) values, resonance frequency analysis (RFA), bone-to-implant contact (BIC), bone mineral density (BMD) and stereological measures of trabecular bone.ResultsA significant positive correlation was found between IT and RFA (r = 0.980, p = 0.0001). BMD at the implant sites was 18% less than the reference values (p = 0.0156). Peri-implant Tb.Th was 50% higher, while Tb.N was 50% lower than the reference zone (p < 0.003) and they were negatively correlated (r = −0.897, p = 0.006).SignificanceμCT increases evaluation throughput and offers the possibility for qualitative three-dimensional recording of the bone–implant system as well as for non-destructive evaluation of bone architecture and mineral density, in combination with conventional analysis methods. The proposed multimodal approach allows to improve accuracy and reproducibility for peri-implant bone measurements and could support future investigations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Dental Materials - Volume 32, Issue 6, June 2016, Pages 794–806
نویسندگان
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