کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1425537 986769 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reduction in inflammation in the footpad of carrageenan treated mice following the topical administration of anti-TNF molecules formulated in a micro-emulsion
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Reduction in inflammation in the footpad of carrageenan treated mice following the topical administration of anti-TNF molecules formulated in a micro-emulsion
چکیده انگلیسی

Water-in-oil micro-emulsions (ME) have been shown to have the ability to deliver water-soluble peptides and proteins into the skin. Topical administration of these formulations represents an ideal means of device-free delivery of these pharmaceutical agents. Topically administered anti-tumor necrosis factor (TNF) monoclonal antibodies formulated within a water-in-oil micro-emulsion were found to have similar pharmaceutical activity to control formulations that were administered by injection. This form of delivery presents itself as an exciting, pain-free and device-free delivery system for administration of protein pharmaceuticals and as such has enormous potential for the delivery of peptides and protein into the dermal layer of the skin.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 145, Issue 3, 3 August 2010, Pages 210–213
نویسندگان
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