کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1425689 986775 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design of iron oxide nanoparticles with different sizes and surface charges for simple and efficient labeling of mesenchymal stem cells
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Design of iron oxide nanoparticles with different sizes and surface charges for simple and efficient labeling of mesenchymal stem cells
چکیده انگلیسی

The objective of this study is to prepare iron oxide nanoparticles with different sizes and surface potentials and evaluate the labeling efficiency of bone marrow-derived mesenchymal stem cells (MSC). The ferric and ferrous ions were co-precipitated in the presence of pullulan or the cationized and anionized derivatives to prepare iron oxide-pullulan nanoparticles of a contrast agent of magnetic resonance imaging (MRI). The size and surface potential of iron oxide-pullulan nanoparticles were changed by altering the mixing molar ratio of pullulan OH groups to ferric ions and the mixing percentage of pullulan derivatives, respectively. When MSC were labeled with the iron oxide-pullulan nanoparticles by the co-culture for 1 h, the labeling efficiency and 1H MRI relaxivity were greatly influenced by the particle size and surface potential, while the labeling procedure did not affect the viability and differentiation ability of MSC. These findings indicate that iron oxide-pullulan nanoparticle is a promising tool for the MRI labeling of MSC.

Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 142, Issue 3, 19 March 2010, Pages 465–473
نویسندگان
, , ,