کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1425775 986779 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticles made from novel starch derivatives for transdermal drug delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Nanoparticles made from novel starch derivatives for transdermal drug delivery
چکیده انگلیسی

The goal of this paper was aimed to the formulation of nanoparticles by using two different propyl-starch derivatives – referred to as PS-1 and PS-1.45 – with high degrees of substitution: 1.05 and 1.45 respectively. A simple o/w emulsion diffusion technique, avoiding the use of hazardous solvents such as dichloromethane or dimethyl sulfoxide, was chosen to formulate nanoparticles with both polymers, producing the PS-1 and PS-1.45 nanoparticles. Once the nanoparticles were prepared, a deep physicochemical characterization was carried out, including the evaluation of nanoparticles stability and applicability for lyophilization. Depending on this information, rules on the formation of PS-1 and PS-1.45 nanoparticles could be developed. Encapsulation and release properties of these nanoparticles were studied, showing high encapsulation efficiency for three tested drugs (flufenamic acid, testosterone and caffeine); in addition a close to linear release profile was observed for hydrophobic drugs with a null initial burst effect. Finally, the potential use of these nanoparticles as transdermal drug delivery systems was also tested, displaying a clear enhancer effect for flufenamic acid.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 141, Issue 1, 4 January 2010, Pages 85–92
نویسندگان
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