کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1427007 986842 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
10-Hydroxycamptothecin loaded nanoparticles: Preparation and antitumor activity in mice
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
10-Hydroxycamptothecin loaded nanoparticles: Preparation and antitumor activity in mice
چکیده انگلیسی

10-Hydroxycamptothecin (HCPT) loaded nanoparticles made from poly(caprolactone-co-lactide)-b–PEG–b-poly(caprolactone-co-lactide) (PCLLA–PEG–PCLLA) block copolymer, were prepared by a novel two-step nanoprecipitation method using an interior-chemistry strategy. The satisfactory drug loading content (> 13%) as well as high encapsulation efficiency (> 85%) was achieved. Cytotoxicity test indicated that the HCPT-loaded nanoparticles had enhanced in vitro cytotoxicity compared to free drug. Progressively, in vivo antitumor activity and HCPT biodistribution in sarcoma-180 (S-180) bearing mice after intravenous injection of the HCPT-loaded nanoparticles show that HCPT-loaded nanoparticles exhibited superior in vivo antitumor effect and remarkably different biodistribution than the commercially available HCPT injection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 119, Issue 2, 1 June 2007, Pages 153–162
نویسندگان
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