کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1429333 987170 2012 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Non-cytotoxic organic–inorganic hybrid bioscaffolds: An efficient bedding for rapid growth of bone-like apatite and cell proliferation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Non-cytotoxic organic–inorganic hybrid bioscaffolds: An efficient bedding for rapid growth of bone-like apatite and cell proliferation
چکیده انگلیسی

Synthesis and characterization of organic–inorganic macroporous hybrid scaffolds were investigated. The materials were prepared by combining 2-hydroxyethylmethacrylate (HEMA) and triethoxyvinylsilane (TEVS) chemically modified by Ca2 + and PO43 − ions via sol–gel route. In this study we have constructed a sugar-based cracks-free three-dimensional (3D) network with interconnected porous architecture within the range of 150–300 μm and rough topography. The obtained results revealed that both topography and composition of prepared materials allow rapid growth of the bone-like apatite (HAp) layer on their surface after soaking in biological medium. Preliminary studies have shown that hybrids covered by HAp are non-cytotoxic and allow cell proliferation that make them a promising scaffolds in the field of bone regenerative medicine. The materials were mainly characterized by powder X-ray diffraction analysis (PXRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy–energy-dispersive spectroscopy (SEM–EDS) and transmission electron microscopy–energy-dispersive spectroscopy (TEM–EDS).

Figure optionsDownload as PowerPoint slideHighlights
► Sol–gel derived biomaterials.
► 3D organic–inorganic hybrid composites for bone tissue engineering.
► Sugar-templated cracks-free macroporous scaffolds.
► 2-hydroxyethylmethacrylate/triethoxyvinylsilane blend doped with calcium and phosphate ions.
► Non-cytotoxic bedding for fibroblasts proliferation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Materials Science and Engineering: C - Volume 32, Issue 7, 1 October 2012, Pages 1849–1858
نویسندگان
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