کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1440016 988031 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Comparative evaluation of humic substances in oral drug delivery
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
پیش نمایش صفحه اول مقاله
Comparative evaluation of humic substances in oral drug delivery
چکیده انگلیسی

Major and biologically most explored components of natural organic matter (NOM) are humic acid (HA) and fulvic acid (FA). We have explored rock shilajit as a source of NOM. On the other hand carbamazepine (CBZ) is a well known anticonvulsant drug and has a limited accessibility to brain. Bioavailability and pharmacokinetic profiles of CBZ have been improved by complexation and different techniques also.Present study has assessed the comparative abilities of FA and HA as complexing agent for CBZ in order to enhance pharmacokinetic profile of CBZ and accessibility to the brain. These two complexing agents have been compared on various indices such as their abilities to cause complexation and enhance solubility, permeability and dissolution. The present study also compared pharmacodynamic and biochemical profiles after oral administration of complexes. With the help of various pharmaceutical techniques such as freeze drying, physical mixture, kneading and solvent evaporation, two molar ratios (1:1 and 1:2) were selected for complexation and evaluated for conformational analysis (molecular modeling). Complex formed was further characterized by differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), mass spectroscopy and X-ray diffraction (XRD).Preclinical study on rodents with CBZ–HA and CBZ–FA has yielded appreciable results in terms of their anticonvulsant and antioxidants activities. However, CBZ–HA (1:2) demonstrated better result than any other complex.

Graphical AbstractFigure optionsDownload high-quality image (133 K)Download as PowerPoint slideHighlights
► Pharmaceutically less explored humic and fulvic acids have been investigated comparatively.
► Their effects on complexation, permeability, release and solubility are studied.
► Permeation, pharmacodynamics, biochemical estimations and pharmacokinetic studies were also evaluated.
► Results pointed out that these could be explored further as pharmaceutical excipients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Results in Pharma Sciences - Volume 1, Issue 1, May 2011, Pages 16–26
نویسندگان
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