کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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148490 | 456416 | 2013 | 5 صفحه PDF | دانلود رایگان |
We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.
• Polysaccharide based thin film nanostructure was created by LbL deposition method.
• Post heat-treatment induced morphological changes in multilayer structures.
• Heat-treated multilayer films result in a sustained release of a growth factor.
Journal: Chemical Engineering Journal - Volume 221, 1 April 2013, Pages 32–36