کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1581 86 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Modeling vancomycin release kinetics from microporous calcium phosphate ceramics comparing static and dynamic immersion conditions
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
Modeling vancomycin release kinetics from microporous calcium phosphate ceramics comparing static and dynamic immersion conditions
چکیده انگلیسی

The release kinetics of vancomycin from calcium phosphate dihydrate (brushite) matrices and polymer/brushite composites were compared using different fluid replacement regimes, a regular replacement (static conditions) and a continuous flow technique (dynamic conditions). The use of a constantly refreshed flowing resulted in a faster drug release due to a constantly high diffusion gradient between drug loaded matrix and the eluting medium. Drug release was modeled using the Weibull, Peppas and Higuchi equations. The results showed that drug liberation was diffusion controlled for the ceramics matrices, whereas ceramics/polymer composites led to a mixed diffusion and degradation controlled release mechanism. The continuous flow technique was for these materials responsible for a faster release due to an accelerated polymer degradation rate compared with the regular fluid replacement technique.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 4, Issue 5, September 2008, Pages 1480–1486
نویسندگان
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