کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
172305 458531 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new algorithm to find all alternate optimal flux distributions of a metabolic network
ترجمه فارسی عنوان
یک الگوریتم جدید برای یافتن توزیع شار مطلوب جایگزین یک شبکه متابولیکی
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
چکیده انگلیسی

Highlight
• A new algorithm is presented to identify all optimal flux distributions of a metabolic network.
• The algorithm consists of two phases: problem reduction and finding optimal vertices.
• The algorithm was applied to find all optimal flux distributions in a genome scale metabolic model.
• This algorithm is more tractable especially for large scale metabolic models.

Finding all optimal solutions for a metabolic model is the challenge of metabolic modeling, but there is no practical algorithm for large scale models. A two-phase algorithm is proposed here to systematically identify all optimal solutions. In phase 1, the model is reduced using the FVA approach; in phase 2, all optimal solutions are searched by the addition of a binary variable to convert the model to an MILP problem. The proposed approach proved itself to be a more tractable method for large scale metabolic models when compared with the previously proposed algorithm. The algorithm was implemented on a metabolic model of Escherichia coli (iJR904) to find all optimal flux distributions. The model was reduced from 1076 to 80 fluxes and from 998 to 54 equations and the MILP problem was solved, resulting in 30,744 various flux distributions. For the first time, this number of optimal solutions has been reported.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 73, 2 February 2015, Pages 64–69
نویسندگان
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