کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
173704 458607 2008 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A stochastic programming approach for clinical trial planning in new drug development
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
A stochastic programming approach for clinical trial planning in new drug development
چکیده انگلیسی

The paper presents a multi-stage stochastic programming formulation for the planning of clinical trials in the pharmaceutical research and development (R&D) pipeline. Scenarios are used to account for the endogenous uncertainty in clinical trial outcomes. Given a portfolio of potential drugs and limited resources, the model determines the trials to be performed in each planning period and scenario. To reduce the size of the formulation we employ a reduced set of scenarios without compromising the quality of uncertainty representation. Furthermore, we present a number of ideas that allow us to reduce the number of non-anticipativity constraints necessary to model indistinguishable scenarios. The proposed approach is the first stochastic programming formulation to address this problem.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computers & Chemical Engineering - Volume 32, Issue 11, 24 November 2008, Pages 2626–2642
نویسندگان
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