کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1760290 1019587 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Contrast-Enhanced Ultrasound with Perflubutane in the Assessment of Anti-Angiogenic Effects: Early Prediction of the Anticancer Activity of Bevacizumab in a Mouse Xenografted Model
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
Contrast-Enhanced Ultrasound with Perflubutane in the Assessment of Anti-Angiogenic Effects: Early Prediction of the Anticancer Activity of Bevacizumab in a Mouse Xenografted Model
چکیده انگلیسی
To investigate the feasibility of contrast-enhanced ultrasound (CEUS) with perflubutane for evaluating anti-angiogenic effects, we assessed the contrast enhancement of mice xenograft treated with bevacizumab. SJSA-1 implanted mice were imaged before and 2, 6, 9 and 13 d after initiation of bevacizumab or saline treatment. Intra-tumoral perfusion areas were quantified by binarizing the ultrasound images and the micro-vessel density was observed by CD31 immunohistochemistry. As a result, the perfusion area and its ratio in the tumor were smaller in the bevacizumab group than the control group at 9 and 13 d, although tumor size was not significantly different. CD31-positive areas were smaller in the bevacizumab group than the control group and correlated well with the ratio of intra-tumoral perfusion areas. CEUS with perflubutane was found to have potential for early prediction of the anti-cancer activity of bevacizumab, and the perfusion area measured by binarized ultrasound images could be used as an indicator.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 41, Issue 9, September 2015, Pages 2497-2505
نویسندگان
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