کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1760452 | 1019594 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative Contrast-Enhanced Ultrasonic Imaging Reflects Microvascularization in Hepatocellular Carcinoma and Prognosis after Resection
ترجمه فارسی عنوان
تصویربرداری التراسونیک با افزایش کنتراست کمی بازتاب دهنده میکروارگانیسم در کارسینوم هپاتوسلولار و پیش آگهی پس از برداشتن
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کلمات کلیدی
سونوگرافی با افزایش کنتراست، تراکم میکروارگانیسم داخل تومور، کارسینوم سلول های خونی پیش بینی،
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
چکیده انگلیسی
Our aim was to evaluate the correlation between tumor vasculature detected by pre-surgical contrast-enhanced ultrasonography and the post-surgical prognosis of patients with hepatocellular carcinoma. One hundred ninety-five patients with hepatocellular carcinoma who had undergone curative resection and pre-operative contrast-enhanced ultrasonography were enrolled. Intra-tumoral microvessels were evaluated by immunohistochemical staining for anti-CD31 and anti-CD34. On the basis of the immunohistochemical staining and morphology patterns, tumors were divided into capillary-like and sinusoid-like microvessel subtypes. The rise time of tumors was shorter in the capillary-like microvessel subtype than in the sinusoid-like microvasculature subtype (p = 0.026). Intra-tumor microvascular density (p < 0.001, hazard ratio = 0.137) and rise time (p = 0.006, hazard ratio = 2.475) were independent factors corresponding to different microvasculature types. Microvascular density, vascular invasion and wash-in perfusion index were determined to be independent factors in recurrence-free survival and overall survival. In conclusion, contrast-enhanced ultrasonography may serve as a means of non-invasive assessment of tumor angiogenesis and may be associated with the survival of patients with hepatocellular carcinoma after resection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 41, Issue 10, October 2015, Pages 2621-2630
Journal: Ultrasound in Medicine & Biology - Volume 41, Issue 10, October 2015, Pages 2621-2630
نویسندگان
Ru-Hai Zou, Qing-Guang Lin, Wei Huang, Xiao-Ling Li, Yun Cao, Jing Zhang, Jian-Hua Zhou, An-Hua Li, Laura Beretta, Chao-Nan Qian,