کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1760514 | 1019607 | 2013 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
High-Throughput, High-Frequency 3-D Ultrasound for in Utero Analysis of Embryonic Mouse Brain Development
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: High-Throughput, High-Frequency 3-D Ultrasound for in Utero Analysis of Embryonic Mouse Brain Development High-Throughput, High-Frequency 3-D Ultrasound for in Utero Analysis of Embryonic Mouse Brain Development](/preview/png/1760514.png)
چکیده انگلیسی
With the emergence of the mouse as the predominant model system for studying mammalian brain development, in utero imaging methods are urgently required to analyze the dynamics of brain growth and patterning in mouse embryos. To address this need, we combined synthetic focusing with a high-frequency (38-MHz) annular-array ultrasound imaging system for extended depth-of-field, coded excitation for improved penetration and respiratory-gated transmit/receive. This combination allowed non-invasive in utero acquisition of motion-free 3-D data from individual embryos in approximately 2Â min, and data from four or more embryos in a pregnant mouse in less than 30Â min. Data were acquired from 148 embryos spanning 5Â d of early to mid-gestational stages of brain development. The results indicated that brain anatomy and cerebral vasculature can be imaged with this system and that quantitative analyses of segmented cerebral ventricles can be used to characterize volumetric changes associated with mouse brain development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 39, Issue 12, December 2013, Pages 2321-2332
Journal: Ultrasound in Medicine & Biology - Volume 39, Issue 12, December 2013, Pages 2321-2332
نویسندگان
Orlando Aristizábal, Jonathan Mamou, Jeffrey A. Ketterling, Daniel H. Turnbull,