کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1761166 | 1019636 | 2011 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Noninvasive Assessment of Atherosclerosis in Apolipoprotein-E Knockout Mice by Ultrasound Biomicroscopy
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Noninvasive Assessment of Atherosclerosis in Apolipoprotein-E Knockout Mice by Ultrasound Biomicroscopy Noninvasive Assessment of Atherosclerosis in Apolipoprotein-E Knockout Mice by Ultrasound Biomicroscopy](/preview/png/1761166.png)
چکیده انگلیسی
Intima media thickness is a marker for human atherosclerosis. This study aimed to validate the hypothesis that atherosclerosis progression in vivo in mice can be visualized noninvasively using high-resolution ultrasound biomicroscopy (UBM), and to study the association between UBM characteristics and plasma lipids in the apolipoprotein-E knockout (ApoE-/-) mouse model. Four age groups of male ApoE-/- mice were used as atherosclerotic models, with age-matched male C57BL/6 mice used as controls. Plaque thickness and area measured by UBM correlated with histologic measurements (r = 0.81, r = 0.70, respectively; p < 0.001). Serum total cholesterol, low density lipoprotein cholesterol and triglycerides were higher in the ApoE-/- groups compared with controls (p < 0.01). Plaque thickness was correlated with total cholesterol (r = 0.505, p < 0.001). High-resolution UBM provides a noninvasive, accurate means of detecting atherosclerosis progression in vivo in mice and can detect changes in the early stage of atherosclerosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 37, Issue 6, June 2011, Pages 892-899
Journal: Ultrasound in Medicine & Biology - Volume 37, Issue 6, June 2011, Pages 892-899
نویسندگان
Yanhong Wang, Ya Yang, Jinjie Xie, Zhian Li, Xiaoshan Zhang, Rongjuan Li,