کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1762440 | 1019693 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effect of Magnetite Nanoparticle Agglomerates on Ultrasound Induced Inertial Cavitation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effect of Magnetite Nanoparticle Agglomerates on Ultrasound Induced Inertial Cavitation Effect of Magnetite Nanoparticle Agglomerates on Ultrasound Induced Inertial Cavitation](/preview/png/1762440.png)
چکیده انگلیسی
High intensity focused ultrasound (HIFU) induced inertial cavitation has been shown to improve release and cellular uptake of drugs. The effects of magnetite nanoparticle agglomerates (290 ± 10 nm diameter), silica coated magnetite nanoparticle agglomerates (320 ± 10 nm diameter) and silica particles (320 ± 10 nm diameter) suspended in MilliQ water on the degree of inertial cavitation due to HIFU were investigated. The HIFU transducer was operated at a frequency of 1.1 MHz, 1.67 kHz pulse repetition frequency, with applied duty cycles (DC) between 0% and 5% and different peak negative focal pressures (PNFPs) applied up to 7.2 MPa. The inertial cavitation dose (ICD: time averaged root-mean-squared broadband noise amplitude in the frequency domain) was measured in the presence and absence of nanoparticles when subjected to HIFU. Magnetite nanoparticle agglomerates caused a significant increase in the ICD above 2.7 MPa PNFP compared with MilliQ water, silica coated magnetite agglomerates and silica particles. With the dramatic increase in ICD on introduction of these magnetite agglomerates, this technique could provide a method of HIFU triggered drug delivery by enhancing inertial cavitation. The superparamagnetic properties of these particles offer the possibility of magnetic targeting to the site of disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 35, Issue 6, June 2009, Pages 1010-1014
Journal: Ultrasound in Medicine & Biology - Volume 35, Issue 6, June 2009, Pages 1010-1014
نویسندگان
Moira J. Smith, Vincent H.B. Ho, Nicholas J. Darton, Nigel K.H. Slater,