کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1762763 1019714 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ultrasound-Induced Thermal Elevation in Clotted Blood and Cranial Bone
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم آکوستیک و فرا صوت
پیش نمایش صفحه اول مقاله
Ultrasound-Induced Thermal Elevation in Clotted Blood and Cranial Bone
چکیده انگلیسی
Ultrasound thermal effects have been hypothesized to contribute to ultrasound-assisted thrombolysis. To explore the thermal mechanism of ultrasound-enhanced thrombolysis with recombinant tissue plasminogen activator (rt-PA) for the treatment of ischemic stroke, a detailed investigation is needed of the heating produced in skull, brain and blood clots. A theoretical model is developed to provide an estimate for the worst-case scenario of the temperature increase in blood clots and on the surface of cranial bone exposed to 0.12- to 3.5-MHz ultrasound. Thermal elevation was also assessed experimentally in human temporal bone, human clots and porcine clots exposed to 0.12 to 3.5-MHz pulsed ultrasound in vitro with a peak-to-peak pressure of 0.25 MPa and 80% duty cycle. Blood clots exposed to 0.12-MHz pulsed ultrasound exhibited a small temperature increase (0.25° C) and bone exposed to 1.0-MHz pulsed ultrasound exhibited the highest temperature increase (1.0° C). These experimental results were compared with the predicted temperature elevations. (E-mail: nahirnvm@email.uc.edu)
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultrasound in Medicine & Biology - Volume 33, Issue 8, August 2007, Pages 1285-1295
نویسندگان
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