کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1790037 1524407 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of surfactant concentration on nifedipine crystal habit and its related pharmaceutical properties
ترجمه فارسی عنوان
اثر غلظت سورفکتانت بر روی عادت کریستال نایفدیپین و خواص دارویی مرتبط با آن
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم فیزیک ماده چگال
چکیده انگلیسی


• Concentration dependent reduction in aspect ratio of Nifedipine with Polysorbate-80.
• Dissolution rate was dependent on the proportion of polar and non-polar facet area.
• Polar dominant surfaces {0 1 1} and {0 0 2} resulted in higher dissolution rate.
• Simulation study was helpful in understanding the cause behind habit modification.

Crystallization in the presence of Polysorbate-80 (T-80), a non-ionic surfactant was explored for crystal habit modification of nifedipine polymorph I (Nif). A concentration dependent reduction in aspect ratio was observed with T-80. Generation of any new solvates/polymorphs was ruled out by Fourier Transform Infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, and thermogravimetric analysis, while the absence of T-80 on the surface or bulk of the recrystallized samples was established by liquid chromatography mass spectroscopy. The dissolution rate order of the re-crystallized Nif habits was in the order of; Nif-D (Nif with 0.6%v/v T-80)>Nif-C (Nif with 0.4% v/v T-80)>Nif-B (Nif with 0.2% v/v T-80)>Nif-A (plain Nif). Wetting ability and surface free energy determination from contact angle measurements were used to explain the order of dissolution rate. The consequences of varying concentration of T-80 on Nif crystal habit was supported by means of molecular dynamics (MD) which was executed using COMPASS force field while modified attachment energy was computed to acquire the absolute morphology. The mechanism for alteration in the morphology was suggested based on the computed crystal surface chemistry. Nif-D crystal habit was nearly iso-diametric with majority of facets occupied by polar dominant surfaces {0 1 1} and {0 0 2} which ultimately resulted in higher dissolution rate. In Nif-B and Nif-C the dissolution rate was dependent on the proportion of polar and non-polar facet area. The methodology used in this study could be an influential tool for selection of concentration of habit-modifying additives in other crystallization studies.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Crystal Growth - Volume 422, 15 July 2015, Pages 44–51
نویسندگان
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