کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1876751 1042031 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Daunorubicin and doxorubicin inhibit the [11C]choline accumulation in cancer cells
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم تشعشع
پیش نمایش صفحه اول مقاله
Daunorubicin and doxorubicin inhibit the [11C]choline accumulation in cancer cells
چکیده انگلیسی

We studied how very short (10–40 min) incubation with anthracycline derivatives modifies the accumulation of PET tumor-diagnostic radiotracers in cancer cells. The human ovarian A2780 and A2780AD, human B lymphoid JY, human epidermoid KB-3-1 and KB-V-1, and smooth muscle DDT1 MF-2 cells were pre-incubated with daunorubicin and doxorubicin, and the uptake of [18F]FDG and [11C]choline was measured. Anthracycline treatment decreased remarkably the [11C]choline accumulation in a concentration dependent manner, while it did not modify significantly the [18F]FDG uptake of the cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Applied Radiation and Isotopes - Volume 67, Issue 10, October 2009, Pages 1806–1811
نویسندگان
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