کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1885466 | 1043422 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Proton Radiotherapy for Liver Tumors: Dosimetric Advantages Over Photon Plans
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
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چکیده انگلیسی
The purpose of the study is to dosimetrically investigate the advantages of proton radiotherapy over photon radiotherapy for liver tumors. The proton plan and the photon plan were designed using commercial treatment planning systems. The treatment target dose conformity and heterogeneity and dose-volume analyses of normal structures were compared between proton and photon radiotherapy for 9 patients with liver tumors. Proton radiotherapy delivered a more conformal target dose with slightly less homogeneity when compared with photon radiotherapy. Protons significantly reduced the fractional volume of liver receiving dose greater or equal to 30 Gy (V30) and the mean liver dose. The stomach and duodenal V45 were significantly lower with the use of proton radiotherapy. The V40 and V50 of the heart and the maximum spinal cord dose were also significantly lower with the use of proton radiotherapy. Protons were better able to spare one kidney completely and deliver less dose to one (generally the left) kidney than photons. The mean dose to the total body and most critical structures was significantly decreased using protons when compared to corresponding photon plans. In conclusion, our study suggests the dosimetric benefits of proton radiotherapy over photon radiotherapy. These dosimetric advantages of proton plans may permit further dose escalation with lower risk of complications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 33, Issue 4, Winter 2008, Pages 259-267
Journal: Medical Dosimetry - Volume 33, Issue 4, Winter 2008, Pages 259-267
نویسندگان
Xiaochun Ph.D., Sunil M.D., Xiaodong Ph.D., Lei Ph.D., Tina Ph.D., Christopher H. M.D., Mary Ph.D., Michael Ph.D., Radhe Ph.D., Sam Ph.D.,