Boolean logic gates based on oxygen-controlled biofuel cell in “one pot”

The present paper is the first report on an enzymatic logic gates system based on oxygen-controlled biofuel cell (BFC). By accepting dual gas-input signals and resulting in the maximum power output changes of the compartmentless BFC with bioanode/biocathode-immobilized enzymes, such system permits AND and XNOR Boolean logic gates readily achieved, reset and interconverted into each other in “one pot”. On the basis of the built-in Boolean XNOR logic, the proof-of-concept oxygen-controlled biocomputing system with miniature BFC operating in serum enabled us to construct a potential self-powered and implantable medical system with the diagnosis aim, which could intellectually make logic decisions that whether the dissolved oxygen content in body fluid is within normal limits or not.

Research highlights
► We report an enzymatic logic gates system based on oxygen-controlled biofuel cell.
► Such system permits AND and XNOR Boolean logic gates readily achieved, reset and interconverted into each other in “one pot”.
► The built-in Boolean XNOR logic enabled us to construct a self-powered and implantable medical system with the diagnosis aim.