کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904503 1534639 2015 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
ترجمه فارسی عنوان
مصرف پتاسیم افزایش یافته، عملکرد شناختی را بهبود می بخشد و نشانگرهای هیستوپاتولوژی را در یک مدل بیماری آلزایمر کاهش می دهد
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by hallmarks that include an accumulation of amyloid-β peptide (Aβ), inflammation, oxidative stress and synaptic dysfunction, which lead to a decrease in cognitive function. To date, the onset and progression of AD have been associated with pathologies such as hypertension and diabetes. Hypertension, a disease with a high incidence worldwide, is characterized by a chronic increase in blood pressure. Interestingly, this disease has a close relationship to the eating behavior of patients because high Na+ intake is a significant risk factor for hypertension. In fact, a decrease in Na+ consumption, along with an increase in K+ intake, is a primary non-pharmacological approach to preventing hypertension. In the present work, we examined whether an increase in K+ intake affects the expression of certain neuropathological markers or the cognitive performance of a murine model of AD. We observed that an increase in K+ intake leads to a change in the aggregation pattern of the Aβ peptide, a partial decrease in some epitopes of tau phosphorylation and improvement in the cognitive performance. The recovery in cognitive performance was correlated with a significant improvement in the generation of long-term potentiation. We also observed a decrease in markers related to inflammation and oxidative stress such as glial fibrillary acidic protein (GFAP), interleukin 6 (IL-6) and 4-hydroxynonenal (4-HNE). Together, our data support the idea that changes in diet, such as an increase in K+ intake, may be important in the prevention of AD onset as a non-pharmacological therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1852, Issue 12, December 2015, Pages 2630-2644
نویسندگان
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