کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1904503 | 1534639 | 2015 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease
ترجمه فارسی عنوان
مصرف پتاسیم افزایش یافته، عملکرد شناختی را بهبود می بخشد و نشانگرهای هیستوپاتولوژی را در یک مدل بیماری آلزایمر کاهش می دهد
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کلمات کلیدی
بیماری آلزایمر، مصرف پتاسیم، فشار خون، اختلال سیناپیک،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by hallmarks that include an accumulation of amyloid-β peptide (Aβ), inflammation, oxidative stress and synaptic dysfunction, which lead to a decrease in cognitive function. To date, the onset and progression of AD have been associated with pathologies such as hypertension and diabetes. Hypertension, a disease with a high incidence worldwide, is characterized by a chronic increase in blood pressure. Interestingly, this disease has a close relationship to the eating behavior of patients because high Na+ intake is a significant risk factor for hypertension. In fact, a decrease in Na+ consumption, along with an increase in K+ intake, is a primary non-pharmacological approach to preventing hypertension. In the present work, we examined whether an increase in K+ intake affects the expression of certain neuropathological markers or the cognitive performance of a murine model of AD. We observed that an increase in K+ intake leads to a change in the aggregation pattern of the Aβ peptide, a partial decrease in some epitopes of tau phosphorylation and improvement in the cognitive performance. The recovery in cognitive performance was correlated with a significant improvement in the generation of long-term potentiation. We also observed a decrease in markers related to inflammation and oxidative stress such as glial fibrillary acidic protein (GFAP), interleukin 6 (IL-6) and 4-hydroxynonenal (4-HNE). Together, our data support the idea that changes in diet, such as an increase in K+ intake, may be important in the prevention of AD onset as a non-pharmacological therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1852, Issue 12, December 2015, Pages 2630-2644
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1852, Issue 12, December 2015, Pages 2630-2644
نویسندگان
Pedro Cisternas, Carolina B. Lindsay, Paulina Salazar, Carmen Silva-Alvarez, Rocio M. Retamales, Felipe G. Serrano, Carlos P. Vio, Nibaldo C. Inestrosa,