کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904625 1534650 2015 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interferon regulatory factors: at the crossroads of immunity, metabolism, and disease
ترجمه فارسی عنوان
عوامل کنترلکننده اینترفرون: در تقاطع ایمنی، متابولیسم و ​​بیماری
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• IRFs are involved not only in immunity, but also in metabolism, and related diseases.
• The roles of IRFs in cardiovascular and cerebrovascular diseases are discussed.
• IRFs are stress sensors.

The interferon-regulatory factor (IRF) family comprises nine members in mammals. Although this transcription factor family was originally thought to function primarily in the immune system, contributing to both the innate immune response and the development of immune cells, recent advances have revealed that IRFs plays critical roles in other biological processes, such as metabolism. Accordingly, abnormalities in the expression and/or function of IRFs have increasingly been linked to disease. Herein, we provide an update on the recent progress regarding the regulation of immune responses and immune cell development associated with IRFs. Additionally, we discuss the relationships between IRFs and immunity, metabolism, and disease, with a particular focus on the role of IRFs as stress sensors. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1852, Issue 2, February 2015, Pages 365–378
نویسندگان
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