کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904633 1534652 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of soluble adenylyl cyclase in neurite outgrowth
ترجمه فارسی عنوان
نقش آدنیلیل سیکلاز محلول در رشد عصبی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
چکیده انگلیسی


• Soluble adenylyl cyclase (sAC) is a novel, non-transmembrane adenylyl cyclase.
• sAC is activated by bicarbonate and cations such as calcium.
• sAC modulates neuronal response to neurotrophins and guidance molecules.
• sAC is important for neuronal survival and regeneration.

Axon regeneration in the mature central nervous system is limited by extrinsic inhibitory signals and a postnatal decline in neurons' intrinsic growth capacity. Neuronal levels of the second messenger cAMP are important in regulating both intrinsic growth capacity and neurons' responses to extrinsic factors. Approaches which increase intracellular cAMP in neurons enhance neurite outgrowth and facilitate regeneration after injury. Thus, understanding the factors which affect cAMP in neurons is of potential therapeutic importance. Recently, soluble adenylyl cyclase (sAC, ADCY10), the ubiquitous, non-transmembrane adenylyl cyclase, was found to play a key role in neuronal survival and axon growth. sAC is activated by bicarbonate and cations and may translate physiologic signals from metabolism and electrical activity into a neuron's decision to survive or regenerate. Here we critically review the literature surrounding sAC and cAMP signaling in neurons to further elucidate the potential role of sAC signaling in neurite outgrowth and regeneration. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1842, Issue 12, Part B, December 2014, Pages 2561–2568
نویسندگان
, , ,