کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1904873 1534677 2012 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Molecular control of rodent spermatogenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Molecular control of rodent spermatogenesis
چکیده انگلیسی

Spermatogenesis is a complex developmental process that ultimately generates mature spermatozoa. This process involves a phase of proliferative expansion, meiosis, and cytodifferentiation. Mouse models have been widely used to study spermatogenesis and have revealed many genes and molecular mechanisms that are crucial in this process. Although meiosis is generally considered as the most crucial phase of spermatogenesis, mouse models have shown that pre-meiotic and post-meiotic phases are equally important. Using knowledge generated from mouse models and in vitro studies, the current review provides an overview of the molecular control of rodent spermatogenesis. Finally, we briefly relate this knowledge to fertility problems in humans and discuss implications for future research. This article is part of a Special Issue entitled: Molecular Genetics of Human Reproductive Failure.


► Molecular control of spermatogenesis.
► Fertility problems in humans.
► Spermatogenesis is a process in which spermatogonial stem cells give rise to spermatids.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1822, Issue 12, December 2012, Pages 1838–1850
نویسندگان
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