Ferulic acid ethyl ester as a potential therapy in neurodegenerative disorders

Oxidative stress is involved in the onset, progression and pathogenesis of a number of diseases including neurodegenerative diseases. It is critical to develop a pharmacological approach to combat oxidative stress which may reduce the risk of diseases and help in promoting healthy life. In an attempt to reduce the side effects associated with allopathic medicines a number of studies are now focusing on developing treatment regimens from naturally occurring plant products. In this review, the protective role of ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA), a naturally occurring antioxidant compound found in fruit, some vegetables, and grains, and its ethyl ester derivative are discussed with respect to neurodegeneration. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.

► Oxidative stress is involved in neurodegenerative diseases.
► Natural antioxidants may protect against oxidative stress related neurodegenerative diseases.
► Ferulic acid (FA) is a naturally occurring antioxidant.
► Use of FA and ferulic acid ethyl ester might limit the side effects associated with drugs.