کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1905099 1534693 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The molecular physiology of nuclear retinoic acid receptors. From health to disease
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
The molecular physiology of nuclear retinoic acid receptors. From health to disease
چکیده انگلیسی

The nuclear retinoic acid (RA) receptors (RARα, β and γ) are transcriptional transregulators, which control the expression of specific gene subsets subsequently to ligand binding and to strictly controlled phosphorylation processes. Consequently RARs maintain homeostasis through the control of cell proliferation and differentiation. Today, it is admitted that, analogous to the paradigm established by the hematopoietic system, most adult tissues depict a differentiation hierarchy starting from rare stem cells. Here we highlight that the integrity of RARs is absolutely required for homeostasis in adults. Indeed, strictly controlled levels of RARs are necessary for the correct balance between self-renewal and differentiation of tissue stem cells. In addition, loss, accumulation, mutations or aberrant modifications of a specific RAR lead to uncontrolled proliferation and/or to differentiation block and thereby to cancer. This article is part of a Special Issue entitled: Translating nuclear receptors from health to disease.

Research highlights
► Advances in RAR functions.
► RARs control cell proliferation and differentiation.
► RAR integrity is required for homeostasis.
► RAR deregulation leads to cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1812, Issue 8, August 2011, Pages 1023–1031
نویسندگان
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