کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1905159 1534691 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phosphorylation, protein kinases and ADPKD
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Phosphorylation, protein kinases and ADPKD
چکیده انگلیسی

Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by renal cyst formation and caused by mutations in the PKD1 and PKD2 genes, which encode polycystin-1(PC-1) and -2 (PC-2) proteins, respectively. PC-1 is a large plasma membrane receptor involved in the regulation of several biological functions and signaling pathways including the Wnt cascade, AP-1, PI3kinase/Akt, GSK3β, STAT6, Calcineurin/NFAT and the ERK and mTOR cascades. PC-2 is a calcium channel of the TRP family. The two proteins form a functional complex and prevent cyst formation, but the precise mechanism(s) involved remains unknown. This article is part of a Special Issue entitled: Polycystic Kidney Disease.


► Growing evidence suggests a role for polycystin-1 in phosphorylation and cell signaling.
► Polycystin-1 regulates several signaling cascades including Wnt, AP-1, PI3kinase/Akt, GSK3β, STAT6, the ERK and mTOR cascades.
► cAMP excess is involved in the pathogenesis of ADPKD.
► Protein kinase X can restore normal function to PKD1-deficient kidneys.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1812, Issue 10, October 2011, Pages 1219–1224
نویسندگان
,