کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1905168 1534691 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells
چکیده انگلیسی

Members of the epidermal growth factor (EGF) family bind to ErbB (EGFR) family receptors which play an important role in the regulation of various fundamental cell processes including cell proliferation and differentiation. The normal rodent kidney has been shown to express at least three members of the ErbB receptor family and is a major site of EGF ligand synthesis. Polycystic kidney disease (PKD) is a group of diseases caused by mutations in single genes and is characterized by enlarged kidneys due to the formation of multiple cysts in both kidneys. Tubule cells proliferate, causing segmental dilation, in association with the abnormal deposition of several proteins. One of the first abnormalities described in cell biological studies of PKD pathogenesis was the abnormal mislocalization of the EGFR in cyst lining epithelial cells. The kidney collecting duct (CD) is predominantly an absorptive epithelium where electrogenic Na+ entry is mediated by the epithelial Na+ channel (ENaC). ENaC-mediated sodium absorption represents an important ion transport pathway in the CD that might be involved in the development of PKD. A role for EGF in the regulation of ENaC-mediated sodium absorption has been proposed. However, several investigations have reported contradictory results indicating opposite effects of EGF and its related factors on ENaC activity and sodium transport. Recent advances in understanding how proteins in the EGF family regulate the proliferation and sodium transport in normal and PKD epithelial cells are discussed here. This article is part of a Special Issue entitled: Polycystic Kidney Disease.

Research Highlights
► ErbB receptors and its ligands involved in renal development, physiology and pathophysiology..
► ErbB activation and mislocalization are important in the progression of PKD.
► EGF and its related growth factors have a biphasic effect on ENaC-mediated sodium absorption.
► ENaC-mediated sodium absorption might be involved in the development of PKD.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1812, Issue 10, October 2011, Pages 1301–1313
نویسندگان
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