کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1905628 1534725 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Bmi1 promotes prostate tumorigenesis via inhibiting p16INK4A and p14ARF expression
چکیده انگلیسی

We report here that the polycomb group protein Bmi1 promotes prostate tumorigenesis. Bmi1 is detected at higher levels in androgen-independent PC3 and DU145 than in androgen-dependent LNCaP prostate cancer (CaP) cells. Ectopic Bmi1 enhanced the expression of human telomerase reverse transcriptase (hTERT) and suppressed the exression of p16INK4A and p14ARF in CaP cells. Consistent with these observations, immunohistochemical staining of 51 cases of primary CaP specimens revealed 1.4 fold (p = 0.014) and 1.3 fold (p = 0.051) higher levels of Bmi1-positive cells in carcinoma compared to normal prostatic epithelial cells and PIN, respectively. In primary CaPs, Bmi1 expression was associated with a reduction in p16INK4A and p14ARF. Furthermore, in comparison to empty vector-transfected cells, Bmi1-expressing DU145 cells formed significantly larger tumors in NOD/SCID mice. Taken together, we demonstrate that Bmi1 promotes prostate tumorigenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1782, Issue 11, November 2008, Pages 642–648
نویسندگان
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