کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1905949 | 1534747 | 2006 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterizing pathogenic processes in Batten disease: Use of small eukaryotic model systems
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Characterizing pathogenic processes in Batten disease: Use of small eukaryotic model systems Characterizing pathogenic processes in Batten disease: Use of small eukaryotic model systems](/preview/png/1905949.png)
چکیده انگلیسی
The neuronal ceroid lipofuscinoses (NCLs) are neurodegenerative disorders. Nevertheless, small model organisms, including those lacking a nervous system, have proven invaluable in the study of mechanisms that underlie the disease and in studying the functions of the conserved proteins associated to each disease. From the single-celled yeast, Saccharomyces cerevisiae and Schizosaccharomyces pombe, to the worm, Caenorhabditis elegans and the fruitfly, Drosophila melanogaster, biochemical and, in particular, genetic studies on these organisms have provided insight into the NCLs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1762, Issue 10, October 2006, Pages 906–919
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1762, Issue 10, October 2006, Pages 906–919
نویسندگان
Seasson N. Phillips, Neda Muzaffar, Sandra Codlin, Christopher A. Korey, Peter E.M. Taschner, Gert de Voer, Sara E. Mole, David A. Pearce,