کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1910629 | 1046780 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of IL-23 in mobilization of immunoregulatory nitric oxide- or superoxide-producing Gr-1+ cells from bone marrow
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کلمات کلیدی
mAbFITCCFASFUl-NMAEAEAPCiNOScomplete Freund's adjuvant - adjuvant دوست کاملmonoclonal Ab - Monoclonal AbN-monométhyl-L-arginine - N-monomethyll-L-arginineNBT, Nitroblue tetrazolium - NBT، Nitroblue tetrazoliumallophycocyanin - آلوفوکسیانینexperimental autoimmune encephalitis - آنسفالیت autoimmune تجربیFree radicals - رادیکال آزادSOD - سدImmunosuppression - سرکوب سیستم ایمنیMyeloid cells - سلولهای میلوئیدیinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییSuperoxide - سوپر اکسیدSuperoxide dismutase - سوکسوکس دیسموتازgranulocyte colony-stimulating factor - فاکتور تحریک کننده کلنی گرانولوسیتG-CSF - فاکتور محرک کُلونی گرانولوسیتfluorescein isothiocyanate - فلوئورسین ایسوتیوسیاناتMycobacterium tuberculosis - مایکوباکتریوم توبرکلوزیسbone marrow - مغز استخوانwild type - نوع وحشیNitric oxide - نیتریک اکسیدAntibody - پادتَن یا آنتیبادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
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چکیده انگلیسی
Spleens of mice injected with heat-killed Mycobacterium tuberculosis increase their Gr-1+ cell content and develop a system of interactive Ly-6G+ and Ly-6GâGr-1+ populations or “Greg” subsets, which, upon stimulation by activated T cells, produce immunoregulatory superoxide (O2â) and nitric oxide (NO), respectively. The balance between immunosuppressive NO and its antagonist O2â regulates T cell expansion, similar to regulation of vasodilation. Reduction of NO levels by O2â is required for efficient T cell expansion and development of autoimmunity. We studied the source of Gr-1+ cells in bone marrow (BM), where their levels were higher than in spleen, with both Greg subsets expressing strong activity. In the spleens of primed IL-23â/â mice, Ly-6G+ cells remained at naïve levels and produced no O2â. The complementary Ly-6GâGr-1+ splenocytes and their suppressive activity were partially reduced. Surprisingly, Gr-1+ cell levels in BM of IL-23â/â mice were increased, as were their O2â and NO production. Transfer of primed BM cells partially restored regulatory function in the spleen of IL-23â/â recipients. The results suggest that IL-23 is involved in mobilization of O2â- and NO-producing Gr-1+ cells from BM, which may contribute to its widely studied role in (auto)immunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 47, Issue 4, 15 August 2009, Pages 357-363
Journal: Free Radical Biology and Medicine - Volume 47, Issue 4, 15 August 2009, Pages 357-363
نویسندگان
Therese A. Dietlin, Daniel J. Cua, Kathleen A. Burke, Brett T. Lund, Roel C. van der Veen,