کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1911166 | 1046804 | 2008 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stress
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کلمات کلیدی
DTNBADDLCM-H2DCFDATNBMALDI/TOFAβ42PMSFSFAMUFATFAGSHHEPESPBSDMEMFBS3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromide5,5′-dithio-bis(2-nitrobenzoic acid) - 5،5'-dithio-bis (2-nitrobenzoic acid)DMSO - DMSODulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده DulbeccoMTT - MTTN-(2-hydroxyethyl)piperazine-N′-(2-ethanesulfonic acid) - N- (2-hydroxyethyl) piperazine-N '- (2-ethanesulfonic acid)ROS - ROSAntioxidants - آنتی اکسیدانTrifluoroacetic acid - اسید Trifluoroaceticsaturated fatty acid - اسید چرب اشباع شدهPolyunsaturated fatty acid - اسید چرب غیر اشباعmonounsaturated fatty acid - اسید چرب غیر اشباعPUFA - اسید چرب چند غیراشباعAlzheimer disease - بیماری آلزایمرOxidative stress - تنش اکسیداتیوBODIPY - جسدDimethyl sulfoxide - دیمتیل سولفواکسیدFree radicals - رادیکال آزادfetal bovine serum - سرم جنین گاوAmyloid toxicity - سمیت آمیلئیدphenylmethylsulfonyl fluoride - فنیل متیل سولفونیل فلورایدPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریMatrix-Assisted Laser Desorption/Ionization Time-of-Flight - مدت زمان پرواز یونیزاسیون لیزر ماتریکس کمک می کندhigh-pressure liquid chromatography - کروماتوگرافی مایع با فشار بالاHPLC - کروماتوگرافی مایعی کاراGlutathione - گلوتاتیونReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent data support the role of oxidative stress in the pathogenesis of Alzheimer disease (AD). In particular, glutathione (GSH) metabolism is altered and its levels are decreased in affected brain regions and peripheral cells from AD patients and in experimental models of AD. In the past decade, interest in the protective effects of various antioxidants aimed at increasing intracellular GSH content has been growing. Because much experimental evidence suggests a possible protective role of unsaturated fatty acids in age-related diseases, we designed the synthesis of new S-acylglutathione (acyl-SG) thioesters. S-Lauroylglutathione (lauroyl-SG) and S-palmitoleoylglutathione (palmitoleoyl-SG) were easily internalized into the cells and they significantly reduced Aβ42-induced oxidative stress in human neurotypic SH-SY5Y cells. In particular, acyl-SG thioesters can prevent the impairment of intracellular ROS scavengers, intracellular ROS accumulation, lipid peroxidation, and apoptotic pathway activation. Palmitoleoyl-SG seemed more effective in cellular protection against Aβ-induced oxidative damage than lauroyl-SG, suggesting a valuable role for the monounsaturated fatty acid. In this study, we demonstrate that acyl-SG derivatives completely avoid the sharp lipoperoxidation in primary fibroblasts from familial AD patients occurring after exposure to Aβ42 aggregates. Hence, we put forward these derivatives as new antioxidant compounds which could be excellent candidates for therapeutic treatment of AD and other oxidative stress-related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 44, Issue 8, 15 April 2008, Pages 1624-1636
Journal: Free Radical Biology and Medicine - Volume 44, Issue 8, 15 April 2008, Pages 1624-1636
نویسندگان
Anna Pensalfini, Cristina Cecchi, Mariagioia Zampagni, Matteo Becatti, Fabio Favilli, Paolo Paoli, Serena Catarzi, Silvia Bagnoli, Benedetta Nacmias, Sandro Sorbi, Gianfranco Liguri,