کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1912128 | 1534991 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material
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کلمات کلیدی
TNFphorbol-12-myristate 13-acetateDMEMMBPPKCCD36HBSSBSA - BSADMSO - DMSOPMA - LDC هاDulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده Dulbeccobovine serum albumin - آلبومین سرم گاوinterferon - اینترفرونIFN - اینترفرون هاinterleukin - اینترلوکینProtein degradation - تخریب پروتئینDimethyl sulfoxide - دیمتیل سولفواکسیدAging - سالخوردگیAge - سنtumor necrosis factor. - عامل نکروز تومورAdvanced glycation end products - محصولات نهایی پیشرفته گلیساسیونHank's balanced salt solution - محلول نمک متعادل هانکMicroglia - میکروگلیاهاVitamin E - ویتامین E Oxidized proteins - پروتئین اکسید شدهMyelin basic protein - پروتئین پایه میلینProtein kinase C - پروتئین کیناز سی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material Tocopherol-mediated modulation of age-related changes in microglial cells: Turnover of extracellular oxidized protein material](/preview/png/1912128.png)
چکیده انگلیسی
Proteins accumulate during aging and form insoluble protein aggregates. Microglia are responsible for their removal from the brain. During aging, changes within the microglia might play a crucial role in the malfunctioning of these cells. Therefore, we isolated primary microglial cells from adult rats and compared their activation status and their ability to degrade proteins to that of microglial cells isolated from newborn animals. The ability of adult microglial cells to degrade proteins is substantially decreased. However, the preincubation of microglial cells with vitamin E improves significantly the degradation of such modified proteins. The degradation of proteins from apoptotic vesicles is decreased in microglia isolated from adult rats. This might be the result of a suppression of the CD36 receptor due to vitamin E treatment. We concluded that microglial cells isolated from adult organisms have different metabolic properties and seem to be a more valuable model to study age-related diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 40, Issue 12, 15 June 2006, Pages 2126-2135
Journal: Free Radical Biology and Medicine - Volume 40, Issue 12, 15 June 2006, Pages 2126-2135
نویسندگان
Alexandra Stolzing, Rebecca Widmer, Tobias Jung, Peter Voss, Tilman Grune,