کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1919245 | 1535613 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aging effects on oxidative phosphorylation in rat adrenocortical mitochondria
ترجمه فارسی عنوان
اثرات پیری بر فسفوریلاسیون اکسیداتیو در میتوکندری آدرنوکورتیک موش صحرایی
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کلمات کلیدی
میتوکندریا، قشر آدرنال، فسفوریلاسیون اکسیداتیو، سالخورده، فیشر 344 موش،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
چکیده انگلیسی
Does aging in itself lead to alteration in adrenocortical mitochondrial oxidative phosphorylation? Mitochondria from Fischer 344 (F344) rats (6 and 24 months old), Brown Norway rats (6 and 32 months old) and F344-Brown Norway hybrid rats (6 and 30 months old) were compared. Mitochondria were isolated from extirpated adrenal cortex. The yields of mitochondria were quantitatively similar in all rat strains irrespective of age. In order to assess the activity of each mitochondrial complex, several different substrates were tested and the rate of oxidative phosphorylation measured. Aging does not affect mitochondrial activity except in the F344 rat adrenal cortex where the maximal ADP-stimulated oxidative phosphorylation decreased with age. We hypothesize that impaired synthesis of steroid hormones by the adrenal cortex with age in F344 rats might be due to decreased adrenocortical mitochondrial oxidative phosphorylation. We conclude that aging results in adrenocortical mitochondria effects that are non-uniform across different rat strains.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mechanisms of Ageing and Development - Volume 138, June 2014, Pages 10-14
Journal: Mechanisms of Ageing and Development - Volume 138, June 2014, Pages 10-14
نویسندگان
Paola Solinas, Hisashi Fujioka, Tomas Radivoyevitch, Bernard Tandler, Charles L. Hoppel,