کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1925241 | 1536355 | 2014 | 11 صفحه PDF | دانلود رایگان |
• The function, structure, and mechanisms are described for nickel-dependent enzymes.
• Nickel active sites range from simple mononuclear centers to complex multi-metal complexes.
• Methods to establish nickel specificity are discussed.
This review describes the functions, structures, and mechanisms of nine nickel-containing enzymes: glyoxalase I, acireductone dioxygenase, urease, superoxide dismutase, [NiFe]-hydrogenase, carbon monoxide dehydrogenase, acetyl-coenzyme A synthase/decarbonylase, methyl-coenzyme M reductase, and lactate racemase. These enzymes catalyze their various chemistries by using metallocenters of diverse structures, including mononuclear nickel, dinuclear nickel, nickel–iron heterodinuclear sites, more complex nickel-containing clusters, and nickel-tetrapyrroles. Selected other enzymes are active with nickel, but the physiological relevance of this metal specificity is unclear. Additional nickel-containing proteins of undefined function have been identified.
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Journal: Archives of Biochemistry and Biophysics - Volume 544, 15 February 2014, Pages 142–152