Human choline dehydrogenase: Medical promises and biochemical challenges

- Mammalian choline dehydrogenase is associated with the inner mitochondrial membrane.
- Human enzyme is implicated in male infertility, homocysteinuria, metabolic syndrome.
- Obtainment of purified, active and stable enzyme from various sources has failed.
- Several active site residues of choline oxidase are conserved in the dehydrogenase.