کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1926410 | 1536459 | 2009 | 10 صفحه PDF | دانلود رایگان |
Neuroinflammation plays an integral role in the progression of neurodegeneration. In this study we investigated the anti-inflammatory effects of different classes of flavonoids (flavanones, flavanols and anthocyanidins) in primary mixed glial cells. We found that the flavanones naringenin and hesperetin and the flavanols (+)-catechin and (−)-epicatechin, but not the anthocyanidins cyanidin and pelargonidin, attenuated LPS/IFN-γ-induced TNF-α production in glial cells. Naringenin also inhibited LPS/IFN-γ-induced iNOS expression and nitric oxide production in glial cells, thus showing the strongest anti-inflammatory activity among all flavonoids tested. Moreover, naringenin protected against inflammatory-induced neuronal death in a primary neuronal–glial co-culture system. Naringenin also inhibited LPS/IFN-γ-induced p38 mitogen-activated protein kinase (MAPK) phosphorylation and downstream signal transducer and activator of transcription-1 (STAT-1) in LPS/IFN-γ stimulated primary mixed glial cells. Taken together, our results suggest that naringenin may produce an anti-inflammatory effect in LPS/IFN-γ stimulated glial cells that may be due to its interaction with p38 signalling cascades and the STAT-1 transcription factor.
Journal: Archives of Biochemistry and Biophysics - Volume 484, Issue 1, 1 April 2009, Pages 100–109