کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1928623 1050380 2014 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inhibitory role of Id1 on TGF-β-induced collagen expression in human dermal fibroblasts
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inhibitory role of Id1 on TGF-β-induced collagen expression in human dermal fibroblasts
چکیده انگلیسی


• Id1-b inhibits TGF-β-induced collagen expression in dermal fibroblasts.
• Id1-b inhibits TGF-β-induced phosphorylation of Smad2 and Smad3.
• Id1 expression was decreased in fibrotic skin diseases while TGF-β signaling was increased.

Inhibitor of DNA binding 1 (Id1) is a basic helix-loop-helix (bHLH) protein that has a variety of functional roles in cellular events including differentiation, cell cycle and cancer development. In addition, it has been demonstrated that Id1 is related with TGF-β and Smad signaling in various biological conditions. In this study, we investigated the effect of Id1 on TGF-β-induced collagen expression in human dermal fibroblasts. When Id1-b isoform was overexpressed, TGF-β-induced collagen expression was markedly inhibited. Consistent with this result, Id1-b significantly inhibited TGF-β-induced collagen gel contraction. In addition, Id1-b inhibited TGF-β-induced phosphorylation of Smad2 and Smad3. Finally, immunohistochemistry showed that Id1 expression was decreased in fibrotic skin diseases while TGF-β signaling was increased. Together, these results suggest that Id1 is an inhibitory regulator on TGF-β-induced collagen expression in dermal fibroblasts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 444, Issue 1, 31 January 2014, Pages 81–85
نویسندگان
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