کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1929057 1050443 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cyclophilin A and viral infections
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Cyclophilin A and viral infections
چکیده انگلیسی

Cyclophilin A (CyPA) is a peptidyl-prolyl cis/trans isomerase originally identified as the target of the immunosuppressive drug cyclosporine A. A number of reports have demonstrated that CyPA plays a critical role in the successful replication of viruses such as human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), etc. However, recent studies demonstrated that CyPA also possesses a repressive effect on the replication of some viruses like Influenza A virus and rotavirus. Moreover, CyPA could also regulate host IFN-I response to viral infections. Together, these evidences showed diverse roles of CyPA in viral infection.


► CyPA plays a critical role in the successful replication of viruses.
► CyPA also possesses a repressive effect on the replication of some viruses.
► CyPA could also regulate host IFN-I response to viral infections.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 424, Issue 4, 10 August 2012, Pages 647–650
نویسندگان
, , , ,