کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1929197 1050448 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
C-terminal truncation of Vascular Endothelial Growth Factor mimetic helical peptide preserves structural and receptor binding properties
چکیده انگلیسی

Vascular Endothelial Growth Factor mimetic peptides have interesting applications in therapeutic angiogenesis. Recently, we described the proangiogenic properties of a 15 mer peptide designed on the N-terminal helix 17–25 of VEGF. The peptide was stabilized introducing well known peptide chemical tools among which N- and C-terminal capping sequence. Here, we show that the C-terminal sequence does not affect the structural and biological properties of the full-length peptide. In fact, a C-terminal truncated analog peptide resulted in a well folded and stable helix retaining the ability to bind to VEGF receptors. This study will allow to develop smaller peptidomimetic analogs able to modulate the VEGF-dependent angiogenesis.


► C-terminal truncated analog of QK is a stable and well folded helix in solution.
► The C-terminal truncated analog of QK binds to VEGF receptors.
► The C-terminal sequence does not affect the structure and biological activity of QK.
► This study will allow the design of smaller peptidomimetic analogs of peptide QK.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 424, Issue 2, 27 July 2012, Pages 290–294
نویسندگان
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