Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: New evidence for a putative novel function of uncoupling proteins as superoxide anion transporters

► GDP and GTP increase accumulation of reactive oxygen species within the mitochondrial matrix. ► UCP2 KO mouse brain mitochondria demonstrate a decreased GDP effect on ROS release. ► Uncoupling proteins, presumably UCP2, may function as transporters of the superoxide anion.