Hypoxia-inducible Factor 1 regulated ARC expression mediated hypoxia induced inactivation of the intrinsic death pathway in p53 deficient human colon cancer cells

► Hypoxia induces ARC mRNA and protein expression in colon cancer cells. ► HIF-1 mediates hypoxia-induced ARC expression. ► HIF-1α activates ARC expression by binding to its promoter region. ► Hypoxia-inhibited Bax translocation during TRAIL-induced cell death was mediated by ARC.