کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1929805 1050475 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systematic screen for genes involved in the regulation of oxidative stress in the nematode Caenorhabditis elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Systematic screen for genes involved in the regulation of oxidative stress in the nematode Caenorhabditis elegans
چکیده انگلیسی

Oxygen is essential for animals, but high concentrations of oxygen are toxic to them probably because of an increase in reactive oxygen species (ROS). Many genes are involved in the regulation of ROS, but they largely remain to be identified. To identify these genes, we employed the nematode Caenorhabditis elegans as a model organism, and systematically screened for genes that, when down-regulated by RNAi, lead to an increased sensitivity to ROS. We examined approximately 2400 genes on linkage group I and found that knock-down of 9 genes which participate in various cellular functions led to an increased sensitivity to ROS. This finding suggests an implication of a variety of cellular processes in the regulation of oxidative stress.


► ROS are important because increased levels of ROS can cause oxidative damage.
► We screened for genes that, when knocked down by RNAi, cause hypersensitivity to ROS in C. elegans.
► We identified 9 genes which participate in various cellular functions from the screening of LG I.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 420, Issue 3, 13 April 2012, Pages 552–557
نویسندگان
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